Objectives

By using an integrated molecular biological bioinformational and in vitro approach this proposal aims at:

- creating an age-specific database using genome wide analysis of regeneration associated genes to identify genetic pathways associated with axonal growth/inhibition in response to injuries to the aged central nervous system. It is crucially important to take these results to a functional level;

- relate genome changes to demonstrable age-related changes in the activity of a number of functional pathway that regulate viability and survival and regeneration.