Discipline of Biochemistry in collaboration with institutions in the country and abroad, is currently carrying out fundamental research with the following main research directions:

- Modern approaches to the diagnosis and therapy of malignant tumours: from cellular mechanisms to potential clinical applications;

- The role of growth factor receptors and tumour stem cells in the diagnosis and therapy of solid tumours;

- Oxidative stress in diabetes and cancer diseases;

- Biochemical analysis of central nervous system regeneration after injury;

- Genomic, biochemical and cellular analysis of neurogenesis in epilepsy.

Research projects:

• ”The use of stem cells in diagnostic and therapy of brain tumours: a role of growth factor receptors”, Principal Investigator, ANCS 2007-2010. Director de proiect: Anica Dricu.

• ”Automatisiertes immunhistologisches Analyse-Gerät” (Dezvoltare echipamente de analiză imunohistochimică automatizată). Director de platformă: Prof. univ. dr Aurel Popa. 2007

• ”Multimodal Approaches for Regenerative Stroke Therapies”. (MARS). Proiect V: Therapeutic benefit of therapeutic concepts in aged rats after stroke.2008. Director de proiect: Aurel Popa.

• Proiect FP7:”Improvement of the research competitiveness in neuroscience at the Ernst Moritz Arndt University of Greifswald”. Director de consorțium: Aurel Popa.

• ”Age-related deterioration of biological pathways and their significance for brain tissue regeneration and functional recuperation after stroke”, (Regeneratome), PN-II-ID-PCE-2011-3-0848 IDEI; 2011-2014, coordonator proiect Popa Aurel

• ”Molecular profiling of stem cell and neurogenic markers in human brain tumours”, nr. 746/01.01.2014, UEFISCDI, PN-II-Capacitati, 2014-2015, Director de proiect: Anica Dricu.

• ”Rolul receptorilor tirozin kinazici în diagnosticul şi terapia tumorilor cerebrale”, nr.134/2011, PNII-ID-PCE-2011-3-1041, UEFISCDI, 2011-2016. Director de proiect: Anica Dricu.

• ”Cellular therapy of stroke”, (CELEST), PCCA 80/2012, coordonator proiect Popa Aurel

• ”Impactul fagocitozei microgliale asupra eficienței terapiei cu celule neuronale stem în accidentul vascular ischemic”, 165/2015, UEFISCDI, PN-II-RU-TE-2014-4-0705, 2015-2017, responsabil proiect Conf. univ. dr. Bugă Ana-Maria

• ”Evaluarea in vitro a efectul acidului salicilic asupra tumorilor cerebrale”, 559/2016, Agenți economici, 2016 – 2017, responsabil proiect Purcaru Ștefana – Oana

• ”Evaluarea unor marcheri de tranziție epitelio-mezenchimală în tumorile cerebrale, Agenţi economici, Nr. 588/2016, 2016 – 2017, responsabil proiect Tache Daniela Elise

• “Restore cell balance in the aged brain after stroke by direct in vivo reprogramming technology” (REPROSTROKE) PN-III-P4-ID-PCE-2016-0340, 2016-2019, coordonator proiect Popa Aurel

• “Development of a novel stem cell-seeded hydrogel to support the recovery of brain structure and function after stroke” (STEMSTROKE) PN-III-CERC-CO-PED-2016, 2017-2019, coordonator proiect Popa Aurel

• „Influența ELTD1 în evoluția și răspunsul la tratament al tumorilor solide”, 548/2018 Agenți economici, 2018 – 2019, responsabil proiect Artene Ștefan – Alexandru

• ”Algoritm de diagnostic al pacientului oncologic cu manifestări neurologice”, 636/2019, Agenți economici, 2019-2020, responsabil proiect Conf.univ. dr. Raluca Elena Sandu

• Proiect mobilitate, Karolinska Institutet, Stockholm, PN-III-P1-1.1-MC-2019-1185, 04/06/2019. Director de proiect: Anica Dricu.

• „Identification and clinical validation of biomarkers for long-term outcome after cerebral ischemia”, (CELEST), ERANET-Neuron, 2020-2023, coordonator proiect Popa Aurel

• Biomarkerii moleculari în era oncologiei de precizie, PN-III-P4-ID-PCE-2020-1649.2021-2023.

Collaborative research projects with other institutions in the country and abroad where Biochemistry teachers are members of the research teams:

• ”Proiect integrat privind noi modele de corelări in vitro - in vivo în scopul reducerii numărului experimentelor de bioechivalență in vivo” director proiect Prof. univ. dr. Constantin Mircioiu, UMF Carol Davila București 2006-2008. Proiect CEEX

• ”Evaluarea stresului oxidativ în expunerea ambientală acută sau cronică la nitraţi/nitriţi, director proiect Conf. Univ. Dr. Ileana Prejbeanu. 2007-2008.

• ”Studiul modificărilor histologice și imunohistochimice din boala ficatului gras non-alcoolic asociată sindromului metabolic”, director proiect Conf. Univ. Dr. Letiția Streba, 2007-2008. Proiect Academia Română.

The results of the fundamental research activity carried out by the teaching staff of the Discipline of Biochemistry were materialized in articles published in journals in the country and abroad, as well as in participation in prestigious scientific events.