Description

  2. Educație
  3. Facultăţi
  4. Medicină
  5. Medicine
  6. Clinical Hematology
  7. Description

Description

 

DISCIPLINE SHEET
 
I. GENERAL INFORMATION
University
UNIVERSITY OF MEDICINE AND PHARMACY OF CRAIOVA
Faculty
MEDICINE
Field of license
HEALTH
Study program
Medicine
Discipline name
Clinical Haematology-Immunopathology
Discipline code
 
II. DISCIPLINE STRUCTURE
Level of studies1)
Semester
Type2) (content)
Type3) (obligation)
Standard activities [hours/week]
Total hours
[hrs/week]
Credits4)
C
S
L
P
TOTAL
 L
I
DS
DI
2 hrs
2 hrs/sem
2 hrs/group
 
4
18
3
 
 
 
 
 
 
 
 
 
 
 
III. DISCIPLINE HOLDER
Name and surname
Găman Gabriel Dragoș
Institution
UMF Craiova
Catedra/Departamentul
4
Scientific title
Doctor of Medicine
Didactic grade
University Professor
Classification (basic/associate norm)
Basic norm
IV. DISCIPLINE OBJECTIVES
 
General objectives:
  1. Acquiring theoretical notions related to the topics discussed in the lecture (iron deficiency anemia, megaloblastic anemia, aplastic anemia, hemolytic anemias, acute, myeloblastic and lymphoblastic leukemias, chronic granulocytic leukemia, chronic lymphatic leukemia, multiple myeloma, Hodgkin's disease, nonHodgkin's malignant lymphomas, hemorrhagic syndromes).
  2. Recognition of normal blood cells on peripheral blood smear, recognition of leukaemic cells, recognition of the main peripheral blood changes in iron deficiency anaemia, megaloblastic anaemia, aplastic anaemia and haemolytic anaemias.
  3. Ability of students to establish a positive diagnosis on a hematology report card.
  4. Knowledge of normal blood constants (haemoglobin, leucogram, platelet count, reticulocyte count, erythrocyte indices, normal medulogram, VSH, serum creatinine, total bilirubinemia and fractions, transaminases, Quick time, Howell, INR, coagulogram).
  5. Interpretation of altered haematological constants in non-haematological conditions.
 
 
Specific objectives: on completion of the subject the student will be able to:
  1. perform a peripheral blood smear.
  2. perform an aspirated spinal tap.
  3. recognise normal and pathological haematomas on a peripheral blood smear.
  4. recognize leukemic blasts on a peripheral blood smear and an MO smear.
  5. recognise Reed-Sternberg cell and myeloma cell on a spinal cord smear.
  6. be able to interpret in context the clinical signs of haematological diseases, with the paraclinical explorations allowing the positive and differential diagnosis of these diseases.
  7. be able to make a correct differential diagnosis in all haematological diseases taught in the lecture.
  8. interpret an electrophoresis and an immunoelectrophoresis.
  9. differentiate an acute leukaemia from a leukaemoid reaction.
  10. be able to have an interactive discussion with colleagues and teaching staff on the topics studied.
 
 
 
V. SPECIFIC COMPETENCES(aims at the competences provided by the study program the subject belongs to)
Upon completion of the course the student will be able to:
1. Define the anemia syndrome, classify anemias (morphologically, etiopathogenetically, functionally, clinically), establish and argue the mechanisms of production of various types of anemias (aplastic, iron deficiency, megaloblastic, acute posthemorrhagic, hemolytic);
    Establish the investigation plan for an anemic syndrome;
  Perform a peripheral blood smear; recognise on peripheral blood smear (FSP) and haematogenous bone marrow smear (MOH) the characteristic features of different types of anaemia;
  Analyze, interpret a hematology report in a patient with anemic syndrome and argue positive and differential diagnosis;   
2. Define and classify acute leukaemias, chronic leukaemias (CLL, CLL), multiple myeloma, malignant lymphomas;
    Identify risk factors and determine their possible intervention in the pathophysiological mechanism of acute myeloblastic leukaemia, acute lymphoblastic leukaemia, chronic granulocytic leukaemia, chronic lymphocytic leukaemia, multiple myeloma and Hodgkin's and non-Hodgkin's lymphoma malignancies;
    Recognize on the FSP and the MOH the characteristic morphological elements for LAM, LAL, LGC, LLC.
    Establish investigation plan for acute leukaemia, LGC, CLL, MM, malignant lymphomas;
   Analyze, interpret a hematology report in a patient with acute leukemia/LGC/LLC/MM/malignant lymphoma and argue positive and differential diagnosis;
   Decide and argue the establishment of pathophysiological principles of treatment in various types of acute/chronic leukaemia, MM, malignant lymphomas.
3. Define and classify thrombocytopenia and disseminated intravascular microcoagulation syndrome;
  Establish the mechanism of production of thrombocytopenia and disseminated intravascular microcoagulation syndrome (DICMS);
    Establish and interpret the investigation plan of a patient with bleeding syndrome/CID/pathological fibrinolysis;
  Analyse, interpret a haematological report in a patient with haemorrhagic syndrome/CID/pathological fibrinolysis and give reasons for the diagnosis.
 Decide and argue the establishment of pathophysiological principles of treatment in haemorrhagic syndrome/CID/pathological fibrinolysis.
 
VI. DISCIPLINE CONTENT
VI.1 Lecture (content units)
Nr. ore
1. Anaemia syndrome
4
   Definition of anaemia syndrome. Mechanisms of production. Classification of anaemias (morphological, functional, pathogenic, clinical). Anaemias produced by central mechanism (medullary aplasia, iron deficiency anaemia, megaloblastic anaemia, simple chronic anaemia). Anaemias produced by peripheral mechanism (acute post-hemorrhagic anaemia, haemolytic anaemias). Anaemias produced by mixed mechanism. Polyglobuli - definition, classification, mechanisms of production. Myelodysplastic syndromes - definition, classification, mechanisms of production.
 
II. Spinal cord aplasia
2
Definition, classification, risk factors, positive and differential diagnosis, symptomatic treatment, classical and modern specific treatment.
 
III. Acute leukaemias
2
Definition, classification, risk factors, positive and differential diagnosis, symptomatic treatment, specific treatment, notions of bone marrow transplant.
 
IV. Chronic myeloproliferative syndrome
 
2
Stem cell disease, etiology, classification, clinical entities, positive and differential diagnosis, course, complications, prognosis, treatment.
 
 
V. Chronic lymphocytic leukaemia
 
2
Etiology, classification, clinical entities, positive and differential diagnosis, staging, evolution, complications, prognosis, treatment.
 
 
VI.Hodgkin's disease
 
2
Etiology, classification, histological types, staging, positive and differential diagnosis, course, complications, prognosis, treatment.
 
 
VI. Non-Hodgkin's malignant lymphoma
2
Etiology, classifications, histological types, staging, positive and differential diagnosis, course, complications, prognosis, treatment.
 
 
VII. Multiple myeloma
2
Etiology, staging, positive and differential diagnosis, evolution, complications, prognosis, treatment.
 
 
VIII.Haemorrhagic syndromes. Haemophilia. ITP.
2
Etiology, positive and differential diagnosis, course, complications, prognosis, treatment.
 
 
VI.2 PRACTICAL WORK (subjects/topics)
No. hrs
1. Anaemias
4
Peripheral blood smear. Normal and pathological blood count. Anaemia investigation plan.
2
Microscopic examination of FSP and MOH anaemias: iron deficiency, megaloblastic, haemolytic.
Interpretation of haematological bulletins.
2
II. Leukocyte series
4
Acute leukaemia investigation plan. Microscopic examination of FSP and MOH acute myeloblastic and lymphoblastic leukaemias. Interpretation of haematological bulletins.
2
Investigation plan for chronic leukaemia (CLL,CLL) and malignant lymphomas. Microscopic examination of FSP and MOH chronic leukaemias. Interpretation of haematological bulletins
2
III. Haemorrhagic syndromes
2
Investigation plan in haemorrhagic syndrome. Investigation plan in DIC. Exploration of pathological fibrinolysis. Interpretation of haematological bulletins
2
VII. BIBLIOGRAPHY
  1. Badea M, Bondari M, Badea D – Mielomul multiplu – Ed Sitech, Craiova 1998.
  2. Bădulescu F, Carlig V, Voicu V – Bazele chimioterapiei antineoplazice, Ed. Didactică și Pedagogică, 1998.
  3. Gaman G, Ciurea T, Badea M – Manual de hematologie – Ed. Sitech, 1998.
  4. Gaman G, Gaman A – Bolile celulei stem, Ed. Sitech 2001.
  5. Gaman G, Gaman A – Leucemiile, Ed. Didactică și Pedagogică București, 1997.
  6. Gaman G, Gaman A – Boli limfoproliferative cronice, Ed. Sitech, 2004.
  7. Harrison, ed. 2008.
  8. Basic Hematology – 2008
  9. Mut Popescu Delia – Hematologie clinică, Ed. Medicală, București, 2000.
  10. Paun R – Tratat de medicină internă – Hematologie clinică – vol I și II, ED. Didactică și Pedagogică, București 1998.
  11. Petrov L și colab. – Manual de hematologie, Ed. Casa Cărții de Știință, Cluj, 1998.
 
 
 
 
 
 
 
VIII. METHODOLOGICAL MILESTONES
Forms of activity
Teaching/learning techniques, materials, resources: lecture, interactive lecture, group work, problem-based learning.
Lecture
Lecture
Practical works
Practical applications and heuristic conversation
Individual study
 Lecture and recommended bibliography
 
IX. RECOVERY PROGRAM
Absences recovery
No. of recoverable absences
Venue
Time 
In charge
Topic scheduling
2
 
Hematology Clinic
Craiova Municipal Hospital
4-15 ian 2013
Rotaru Ionela
Test only for truant students in all subjects ( lectures) taught during the period they were absent
Consultation programme/
student scientific forum
Thursdays, 16.00- 18.00 at the discipline headquarters
 
 
 
 
Program for poorly prepared students
Thursdays, 16.00- 18.00 at the discipline headquarters
 
 
 
 
 
X. EVALUATION
Form of activity
Evaluation
(written, written and oral, oral, test, practical application, others)
 Percentage of final grade
 
 Formative Periodical Summative
 
Lecture
oral
written
written and oral
10%
Practical works
oral
oral
oral
10%
Exam
oral
oral
oral
70%
Check
written
 written written
10%
 
XI. CAREER GUIDANCE AND COUNSELLING PROGRAMMES
Career guidance and counselling programmes (2 hours/month)
Schedule hours Venue In charge
Thursdays 16.00-18.00
Hematology Clinic
Găman Gabriel
Data avizării în departament:
                                                                                             
Şef de departament,
NUME PRENUME
Coordonator program de studii,
NUME PRENUME
Titular disciplină,
 NUME PRENUME
 
Note:
1)         Level of studies - choose one of the following: L (bachelor)/ M (master)/ D (doctorate).
2)         Type (content) - choose one of the variants:
-         for undergraduate level: DF (fundamental discipline)/ DD (discipline in the field)/ DS (specialist discipline)/ DC (complementary discipline);
-         for master level: DA (further training)/ DS (synthesis discipline)/ DCA (advanced knowledge discipline).
3)         Type (mandatory) - choose one of the variants: DI (mandatory discipline)/ DO (optional discipline)/ DFac (optional discipline).
4)         One credit is equivalent to 25 - 30 hours of study (teaching activities and individual study).
5)       An attendance bonus may be granted.
Actualizat la 14.03.2024, 13:45